Immune check point inhibitors monoclonal antibodies

 The paper should be about 3000 words long The title of the paper is: Describe the therapeutic rationale for two molecular targets of the immune check point inhibitor (ICI) monoclonal antibodies (mAbs) currently on the market, naming ONE example mAb for each target. Discuss the main efficacy and safety data in one of the approved indications for each of the named mAbs. ( the approved indications do not necessarily have to be the same for both mAbs). Points to consider for the essay: should include a therapeutic rationale for 2 molecular targets. Each mAb could have a different indication. should include how is the biology of the target related to the indication, is the target involved in a particular cancer? How is the target involved in cancer with evidence. cancer cells may over-express a specific target ( mentioned in literature).